Basic to Advance Training on Structure-based Drug Design & Vaccine Design

About Course

Welcome to the “Basic to Advanced Training on Structure-based Drug Design & Vaccine Design” course! In this comprehensive program, you’ll journey from foundational concepts to advanced techniques in the dynamic fields of structure-based drug design and vaccine design. Whether you’re a beginner eager to explore the fundamentals or a seasoned researcher looking to refine your skills, this course offers an immersive learning experience tailored to your needs. Join us as we delve into the intricate world of drug design, molecular structures, computational modeling, and bioinformatics tools, and unlock the potential to revolutionize drug discovery and vaccine development.

Are you ready to dive into the forefront of biomedical innovation? Let’s begin!

In this course, "Basic to Advance Training on Structure-based Drug Design & Vaccine Design," you will acquire a robust skill set and deep understanding in two pivotal areas of biomedical research. Here's what you will learn:
1. Foundational Concepts
2. Structure-Based Drug Design (SBDD)
3. Immunoinformatics and Vaccine Design
4. Integration of Computational and Experimental Techniques
By the end of the course, you will be equipped with the knowledge and skills to contribute to cutting-edge research in drug discovery and vaccine development. Whether you aspire to pursue a career in pharmaceutical research, academic science, or healthcare, this course will empower you to make significant contributions to advancing human health and well-being.

Course Content

Lectures on Basic Concept-Introduction with Computer Aided Drug Design (CADD)

Instruction with CADD

00:12
What is Drug Design & Discovery

00:12
Basic Question for previous Lessons

Introduction various type of databases

Lead/Ligand Design and Optimization

Computational Chemistry

Target Protein Identification & Preparation

Homology Modeling (3D Structure Prediction)

Molecular Docking

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About Course

What Will You Learn?

Course Content

Lectures on Basic Concept-Introduction with Computer Aided Drug Design (CADD)

Instruction with CADD

What is Drug Design & Discovery

Basic Question for previous Lessons

Introduction various type of databases

Introduction with related databases for CADD

Lead/Ligand Design and Optimization

Compound’s 2D Structure Drawing by ChemDraw Software

3D Structure Making and Different Type of File Format.

Retrieved Different Fingerprints of the Molecules (SMILE, Inch, InchKEY).

Ligand Selection and Ligand Library Management for Molecular Docking Study.

Drug Likeliness & ADME/T Prediction

Computational Chemistry

Basic Conecptual Lecture on Computational Chemistry

Draw a Ligand or Complex Structure in GaussView 6.0

Gaussian Calculation for Optimization, Energy Minimization, Frequency Calculation using DFT

Results Evaluation: MEP, FMOs (HOMO, LUMO), IR, NMR, RAMAN, Dipole Moment, Total Energy, etc.

Gaussian Calculation using TD-DFT for analyzing UV Spectra.

Target Protein Identification & Preparation

Target Protein deification Based on a Diseases.

Target Protein Download from Different Type of Database

Binding Site or Active Site Prediction.

Protein Preparation, Cleaning, & Energy Minimization.

Homology Modeling (3D Structure Prediction)

Protein FASTA Sequence Retrieval.

Protein BLAST for Similarity/Homology Sequence Search.

Choose a Correct Template and Homology Modeling

Model Evaluation, Validation, and Analysis (Ramachandran Plot).

Molecular Docking

Theoretical Conceptual Lecture on Molecular Docking

Ligand Library Building & Ligand Preparation.

Protein Selection & pdqt file Conversion for Docking

Active Site Define and Grid Parameter Collection

Docking Run and Binding Affinity Interpretation

Protein-Ligand Complex Building and Non-bonding Interaction Analysis

Publishable 2D & 3D image generation and Extraction

Student Ratings & Reviews

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